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ShedRx vs TMates: GLP-1 Comparison 2026

ShedRx vs TMates: pricing, medication type, clinical support, and which mid-market GLP-1 patient each program fits. Both programs’ prices verified July 2026 or later; each price carries its own date in the table below.

By RangeYourselfUpdated September 3, 20264 min read

Quick answer

ShedRx and TMates both offer GLP-1 telehealth, but they package medication, support, and pricing differently. The right choice depends on whether you weight cost, clinical touch, or formulation flexibility highest.

Side-by-side comparison

Feature	ShedRx	TMates
Best for	Broad GLP-1 menu and multiple formats	Compounded GLP-1 with hands-on clinical touch
Medication type	Compounded and brand-name options	Compounded GLP-1 with bundled clinical support
Pricing model	Starting prices by product	Monthly subscription, dose-tier pricing
Semaglutide price	Compounded semaglutide injection $199/mo month-to-month, $179/mo on a 6-month plan, $159/mo on a 12-month plan (product page plan table, verified 2026-09-03 on tryshed.com/products/compounded-semaglutide-injections); the category page card simultaneously advertises 'Starting at $249/month' for the same product (verified same day). Shed's own two surfaces disagree; both are recorded. GLP-1 lozenges from $199/mo; GLP-1 liquid drops from $229/mo; oral semaglutide liposomal tablets from $299/mo, verified 2026-09-03 on tryshed.com/products/category/weight-loss	From $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included
Tirzepatide price	From $349/mo (compounded injection), verified 2026-09-03 on tryshed.com/products/category/weight-loss (unchanged since 2026-07-21)	From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month)
Key watchout	Verify higher-dose pricing and exact formulation before checkout	The $158 headline is the compounded SEMAGLUTIDE plan (12-month term; $249/mo month-to-month). Tirzepatide costs more ($167/mo on a 12-month plan, $297 month-to-month), confirm your product and term at checkout
Price checked	Checked by a person September 3, 2026 · an automated check re-read it September 21, 2026	Checked by a person July 14, 2026 · an automated check re-read it September 21, 2026

When to choose ShedRx

You want both compounded and brand-name options on one menu
You prefer multiple formulation formats (injection, oral, sublingual where offered)
You're starting at a low dose and want a low entry price
You value being able to switch products without changing programs

Check current ShedRx pricing →

When to choose TMates

You want a compounded program with clinical check-ins built in
You'd rather pay one bundled monthly fee than line items
You want responsive messaging with prescribers
You're comfortable with a longer onboarding intake in exchange for support

Check current TMates pricing →

Full reviews

Frequently asked questions

Is ShedRx cheaper than TMates?

TMates starts lower on semaglutide (From $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included). TMates starts lower on tirzepatide (From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month)). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.

Which is better for semaglutide or tirzepatide, ShedRx or TMates?

TMates starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.

Are ShedRx and TMates compounded or brand-name?

ShedRx offers compounded and brand-name options. TMates offers compounded glp-1 with bundled clinical support. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.

Can I switch from ShedRx to TMates?

Yes, switching between ShedRx and TMates is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.

Compare ShedRx and TMates to other programs

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Related guides

About compounded GLP-1 medicationsCompounded semaglutide and tirzepatide are not FDA-approved finished products. They are prepared by state-licensed 503A pharmacies or 503B outsourcing facilities and are not individually reviewed by the FDA for safety, effectiveness, or quality. Compounders describe these preparations as using the same active ingredient as the approved medicines; the FDA has warned that some compounded products use salt forms, semaglutide sodium or semaglutide acetate, that it considers different active ingredients from the approved drug, and has issued warning letters over marketing that presents a compounded preparation as interchangeable with an approved one. The FDA declared the semaglutide shortage resolved on February 21, 2025 and the tirzepatide shortage resolved in December 2024, so the shortage-era pathway for broad compounding of these drugs has ended. Compounding now proceeds under the ordinary rules: a 503A pharmacy compounding for an individual patient on a prescription, or a 503B outsourcing facility, which compounds in bulk under CGMP and FDA registration rather than per patient. Those rules generally do not cover a product that is “essentially a copy” of an approved drug unless a prescriber documents a change that makes a significant difference for an individual patient. Talk to a clinician about contraindications including personal or family history of medullary thyroid carcinoma or MEN 2. RangeYourself does not provide medical advice, does not guarantee a prescription, and does not guarantee weight-loss results.

RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers, verified on the dates shown in the table above, and may change. Numbers like Compounded semaglutide injection $199/mo month-to-month, $179/mo on a 6-month plan, $159/mo on a 12-month plan (product page plan table, verified 2026-09-03 on tryshed.com/products/compounded-semaglutide-injections); the category page card simultaneously advertises 'Starting at $249/month' for the same product (verified same day). Shed's own two surfaces disagree; both are recorded. GLP-1 lozenges from $199/mo; GLP-1 liquid drops from $229/mo; oral semaglutide liposomal tablets from $299/mo, verified 2026-09-03 on tryshed.com/products/category/weight-loss and $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included are starting tiers, not your guaranteed long-term cost.