Quick answer
Direct Meds typically wins on sticker price for compounded GLP-1, while ShedRx bundles more clinical support and often a wider menu of options. Choose Direct Meds if you're price-first; choose ShedRx if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Direct Meds | ShedRx |
|---|---|---|
| Best for | Lowest sticker price for compounded GLP-1 | Broad GLP-1 menu and multiple formats |
| Medication type | Compounded semaglutide and tirzepatide | Compounded and brand-name options |
| Pricing model | Flat low monthly price, minimal extras | Starting prices by product |
| Semaglutide price | From $149/mo | From $175/mo |
| Tirzepatide price | From $219/mo | From $245/mo |
| Key watchout | Lean clinical support — works best if you don't need hand-holding | Verify higher-dose pricing and exact formulation before checkout |
When to choose Direct Meds
- You're price-sensitive and want the lowest defensible monthly cost
- You're already familiar with GLP-1 dosing and side-effect management
- You don't need a coach or a heavy-touch clinical team
- You want a no-frills, predictable monthly bill
Check current Direct Meds pricing →
When to choose ShedRx
- You want both compounded and brand-name options on one menu
- You prefer multiple formulation formats (injection, oral, sublingual where offered)
- You're starting at a low dose and want a low entry price
- You value being able to switch products without changing programs
Check current ShedRx pricing →
Full reviews
Frequently asked questions
Is Direct Meds cheaper than ShedRx?
Direct Meds starts lower on semaglutide (From $149/mo). Direct Meds starts lower on tirzepatide (From $219/mo). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide — Direct Meds or ShedRx?
Direct Meds starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are Direct Meds and ShedRx compounded or brand-name?
Direct Meds offers compounded semaglutide and tirzepatide. ShedRx offers compounded and brand-name options. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Direct Meds to ShedRx?
Yes — switching between Direct Meds and ShedRx is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Direct Meds and ShedRx to other programs
- Direct Meds vs TMates · ShedRx vs TMates
- Direct Meds vs Sprout Health · ShedRx vs Sprout Health
- Direct Meds vs Mochi Health · ShedRx vs Mochi Health
- Direct Meds vs Henry Meds · ShedRx vs Henry Meds
- Direct Meds vs Calibrate · ShedRx vs Calibrate
- Direct Meds vs Embody · ShedRx vs Embody
- Direct Meds vs Found · ShedRx vs Found
- Direct Meds vs FuturHealth · ShedRx vs FuturHealth
RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like $149/mo and $175/mo are starting tiers, not your guaranteed long-term cost.