Quick answer
Yucca Health typically wins on sticker price for compounded GLP-1, while Calibrate bundles more clinical support and often a wider menu of options. Choose Yucca Health if you're price-first; choose Calibrate if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Calibrate | Yucca Health |
|---|---|---|
| Best for | Coaching-heavy, behavior-change-first program | Low advertised entry price on compounded GLP-1 with plain FDA disclosures and all-50-state provider coverage |
| Medication type | Brand-name GLP-1 paired with coaching | Compounded semaglutide and tirzepatide — once-weekly injection ('Semaglutide+' / 'Tirzepatide+'); also sells NAD+ and Sermorelin (out of registry scope) |
| Pricing model | Annual or recurring program fee | 6-month prescription plans billed monthly/quarterly/6-month; advertised new-patient entry pricing; full pricing shared after intake |
| Semaglutide price | Membership $199/mo (3-month commitment); medication via insurance, copays ≤$25/mo | Compounded — '$146 /mo 6 month supply' ('*New Patients, Semaglutide 6-month plan'; 'as low as' entry rate, promo code YUCCA4LIFE '$146 /mo For life' active; full pricing intake-gated) |
| Tirzepatide price | Membership $199/mo (3-month commitment); medication via insurance, copays ≤$25/mo | Compounded — '$258 /mo 6 month supply' (new-patient 6-month plan entry rate; full pricing intake-gated) |
| Key watchout | Higher overall cost — best when you'll use the coaching | The $146/mo figure is a NEW-PATIENT 'as low as' rate on a 6-month semaglutide plan, shown site-wide with an 'Exclusive Lifetime Offer' promo code (YUCCA4LIFE) — Yucca's own FAQ says full pricing 'is shared after intake once eligibility is confirmed.' Confirm your dose's ongoing rate at intake. Pharmacies are not named. |
When to choose Calibrate
- You want a structured behavior-change program, not just a script
- You expect to use coaching, lessons, and tracking actively
- You're committed for a year and want a single program fee
- You prefer brand-name medication routed through your insurance
Check current Calibrate pricing →
When to choose Yucca Health
- You want a low advertised entry price on compounded semaglutide or tirzepatide
- You value an upfront 'not FDA-approved' compounding disclosure in the FAQ
- You want provider coverage in all 50 states with free 2-day shipping
- You're comfortable confirming your exact ongoing rate at intake (pricing beyond the entry offer is shared after eligibility)
Check current Yucca Health pricing →
Full reviews
Frequently asked questions
Is Calibrate cheaper than Yucca Health?
Yucca Health starts lower on semaglutide (Compounded — '$146 /mo 6 month supply' ('*New Patients, Semaglutide 6-month plan'; 'as low as' entry rate, promo code YUCCA4LIFE '$146 /mo For life' active; full pricing intake-gated)). Calibrate starts lower on tirzepatide (Membership $199/mo (3-month commitment); medication via insurance, copays ≤$25/mo). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide — Calibrate or Yucca Health?
Yucca Health tends to win on semaglutide entry pricing; Calibrate tends to win on tirzepatide entry pricing. Pick by which medication you'll be on long-term, not by the cheapest entry tier.
Are Calibrate and Yucca Health compounded or brand-name?
Calibrate offers brand-name glp-1 paired with coaching. Yucca Health offers compounded semaglutide and tirzepatide — once-weekly injection ('semaglutide+' / 'tirzepatide+'); also sells nad+ and sermorelin (out of registry scope). If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Calibrate to Yucca Health?
Yes — switching between Calibrate and Yucca Health is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Calibrate and Yucca Health to other programs
- Calibrate vs ShedRx · Yucca Health vs ShedRx
- Calibrate vs TMates · Yucca Health vs TMates
- Calibrate vs Direct Meds · Yucca Health vs Direct Meds
- Calibrate vs Sprout Health · Yucca Health vs Sprout Health
- Calibrate vs Mochi Health · Yucca Health vs Mochi Health
- Calibrate vs Henry Meds · Yucca Health vs Henry Meds
- Calibrate vs Embody · Yucca Health vs Embody
- Calibrate vs Found · Yucca Health vs Found
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RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Membership $199/mo (3-month commitment); medication via insurance, copays ≤$25/mo and Compounded — '$146 /mo 6 month supply' ('*New Patients, Semaglutide 6-month plan'; 'as low as' entry rate, promo code YUCCA4LIFE '$146 /mo For life' active; full pricing intake-gated) are starting tiers, not your guaranteed long-term cost.