Quick answer
Trimi typically wins on sticker price for compounded GLP-1, while Enhance MD bundles more clinical support and often a wider menu of options. Choose Trimi if you're price-first; choose Enhance MD if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Enhance MD | Trimi |
|---|---|---|
| Best for | Shoppers who want GLP-1 inside a fuller metabolic/NAD+ coaching program rather than medication-only | Lowest-cost compounded GLP-1 on an annual plan with a plain 503A disclosure |
| Medication type | Compounded GLP-1 (semaglutide, tirzepatide, combo, microdosing) offered inside a 'Metabolic Reset' program with NAD+ and coaching | Compounded semaglutide and compounded tirzepatide, once-weekly at-home injection |
| Pricing model | Premium metabolic-program subscription, the monthly price bundles medication, ongoing provider care, and lab testing (not GLP-1 alone) | Flat-membership subscription billed yearly (annual commitment tier); one price covers medication, clinician visits, check-ins, shipping; no separate membership fee; no insurance |
| Semaglutide price | Compounded, 'GLP-1 Core' $212/mo bundled program ($112 first month), verified 2026-07-14. Price reflects the metabolic program, not GLP-1 alone. | Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. |
| Tirzepatide price | Compounded, 'GLP-1 Advanced' $280/mo; combo 'GLP-1 Elite' $322/mo; microdosing tirzepatide $169/mo, all bundled-program prices, verified 2026-07-14. | Compounded, $125/mo on the annual plan (billed yearly). Verified 2026-07-14. |
| Key watchout | The $212–$322/mo figures are the BUNDLED program price, verified first-party to include '4 Weeks of Medication', 'Ongoing Provider Care & Support', and 'Metabolic Lab Testing Every 6 Months', NOT the cost of the GLP-1 medication alone. A first-month discount applies (e.g. $112 first month on GLP-1 Core). | The $99/mo semaglutide and $125/mo tirzepatide rates are the ANNUAL plan, BILLED YEARLY (semaglutide = $1,188 charged up front). A month-to-month rate is not published, confirm billing terms before enrolling. |
When to choose Enhance MD
- You want GLP-1 inside a structured metabolic program (provider care + periodic lab testing), not medication-only
- You’re comparing NAD+/longevity-style programs, not just low-cost GLP-1
- You value an upfront 'compounded / not FDA-approved' disclosure
- You’re comfortable that the monthly price bundles services beyond the medication
Check current Enhance MD pricing →
When to choose Trimi
- You want the lowest-cost compounded semaglutide ($99/mo) or tirzepatide ($125/mo) with everything bundled
- You’re comfortable with an annual plan billed yearly ($1,188 up front for semaglutide)
- You value an upfront '503A compounding pharmacy' and 'not FDA-approved' disclosure
- You want care via a 50-state clinical network (Arora Health) with free shipping
Full reviews
Frequently asked questions
Is Enhance MD cheaper than Trimi?
Trimi starts lower on semaglutide (Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14.). Trimi starts lower on tirzepatide (Compounded, $125/mo on the annual plan (billed yearly). Verified 2026-07-14.). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide, Enhance MD or Trimi?
Trimi starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are Enhance MD and Trimi compounded or brand-name?
Enhance MD offers compounded glp-1 (semaglutide, tirzepatide, combo, microdosing) offered inside a 'metabolic reset' program with nad+ and coaching. Trimi offers compounded semaglutide and compounded tirzepatide, once-weekly at-home injection. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Enhance MD to Trimi?
Yes, switching between Enhance MD and Trimi is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Enhance MD and Trimi to other programs
- Enhance MD vs ShedRx · Trimi vs ShedRx
- Enhance MD vs TMates · Trimi vs TMates
- Enhance MD vs Direct Meds · Trimi vs Direct Meds
- Enhance MD vs Sprout Health · Trimi vs Sprout Health
- Enhance MD vs Mochi Health · Trimi vs Mochi Health
- Enhance MD vs Henry Meds · Trimi vs Henry Meds
- Enhance MD vs Calibrate · Trimi vs Calibrate
- Enhance MD vs Embody · Trimi vs Embody
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RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Compounded, 'GLP-1 Core' $212/mo bundled program ($112 first month), verified 2026-07-14. Price reflects the metabolic program, not GLP-1 alone. and Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. are starting tiers, not your guaranteed long-term cost.