Quick answer
Trimi typically wins on sticker price for compounded GLP-1, while ShedRx bundles more clinical support and often a wider menu of options. Choose Trimi if you're price-first; choose ShedRx if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | ShedRx | Trimi |
|---|---|---|
| Best for | Broad GLP-1 menu and multiple formats | Lowest-cost compounded GLP-1 on an annual plan with a plain 503A disclosure |
| Medication type | Compounded and brand-name options | Compounded semaglutide and compounded tirzepatide — once-weekly at-home injection |
| Pricing model | Starting prices by product | Flat-membership subscription billed yearly (annual commitment tier); one price covers medication, clinician visits, check-ins, shipping; no separate membership fee; no insurance |
| Semaglutide price | From $299/mo (injection); lozenges from $199/mo | Compounded — $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. |
| Tirzepatide price | From $399/mo (injection) | Compounded — $125/mo on the annual plan (billed yearly). Verified 2026-07-14. |
| Key watchout | Verify higher-dose pricing and exact formulation before checkout | The $99/mo semaglutide and $125/mo tirzepatide rates are the ANNUAL plan, BILLED YEARLY (semaglutide = $1,188 charged up front). A month-to-month rate is not published — confirm billing terms before enrolling. |
When to choose ShedRx
- You want both compounded and brand-name options on one menu
- You prefer multiple formulation formats (injection, oral, sublingual where offered)
- You're starting at a low dose and want a low entry price
- You value being able to switch products without changing programs
Check current ShedRx pricing →
When to choose Trimi
- You want the lowest-cost compounded semaglutide ($99/mo) or tirzepatide ($125/mo) with everything bundled
- You’re comfortable with an annual plan billed yearly ($1,188 up front for semaglutide)
- You value an upfront '503A compounding pharmacy' and 'not FDA-approved' disclosure
- You want care via a 50-state clinical network (Arora Health) with free shipping
Full reviews
Frequently asked questions
Is ShedRx cheaper than Trimi?
Trimi starts lower on semaglutide (Compounded — $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14.). Trimi starts lower on tirzepatide (Compounded — $125/mo on the annual plan (billed yearly). Verified 2026-07-14.). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide — ShedRx or Trimi?
Trimi starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are ShedRx and Trimi compounded or brand-name?
ShedRx offers compounded and brand-name options. Trimi offers compounded semaglutide and compounded tirzepatide — once-weekly at-home injection. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from ShedRx to Trimi?
Yes — switching between ShedRx and Trimi is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare ShedRx and Trimi to other programs
- ShedRx vs TMates · Trimi vs TMates
- ShedRx vs Direct Meds · Trimi vs Direct Meds
- ShedRx vs Sprout Health · Trimi vs Sprout Health
- ShedRx vs Mochi Health · Trimi vs Mochi Health
- ShedRx vs Henry Meds · Trimi vs Henry Meds
- ShedRx vs Calibrate · Trimi vs Calibrate
- ShedRx vs Embody · Trimi vs Embody
- ShedRx vs Found · Trimi vs Found
Related guides
RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like $299/mo (injection); lozenges from $199/mo and Compounded — $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. are starting tiers, not your guaranteed long-term cost.