Quick answer
Trimi typically wins on sticker price for compounded GLP-1, while TMates bundles more clinical support and often a wider menu of options. Choose Trimi if you're price-first; choose TMates if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | TMates | Trimi |
|---|---|---|
| Best for | Compounded GLP-1 with hands-on clinical touch | Lowest-cost compounded GLP-1 on an annual plan with a plain 503A disclosure |
| Medication type | Compounded GLP-1 with bundled clinical support | Compounded semaglutide and compounded tirzepatide — once-weekly at-home injection |
| Pricing model | Monthly subscription, dose-tier pricing | Flat-membership subscription billed yearly (annual commitment tier); one price covers medication, clinician visits, check-ins, shipping; no separate membership fee; no insurance |
| Semaglutide price | From $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included | Compounded — $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. |
| Tirzepatide price | From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month) | Compounded — $125/mo on the annual plan (billed yearly). Verified 2026-07-14. |
| Key watchout | The $158 headline is the compounded SEMAGLUTIDE plan (12-month term; $249/mo month-to-month). Tirzepatide costs more ($167/mo on a 12-month plan, $297 month-to-month) — confirm your product and term at checkout | The $99/mo semaglutide and $125/mo tirzepatide rates are the ANNUAL plan, BILLED YEARLY (semaglutide = $1,188 charged up front). A month-to-month rate is not published — confirm billing terms before enrolling. |
When to choose TMates
- You want a compounded program with clinical check-ins built in
- You'd rather pay one bundled monthly fee than line items
- You want responsive messaging with prescribers
- You're comfortable with a longer onboarding intake in exchange for support
Check current TMates pricing →
When to choose Trimi
- You want the lowest-cost compounded semaglutide ($99/mo) or tirzepatide ($125/mo) with everything bundled
- You’re comfortable with an annual plan billed yearly ($1,188 up front for semaglutide)
- You value an upfront '503A compounding pharmacy' and 'not FDA-approved' disclosure
- You want care via a 50-state clinical network (Arora Health) with free shipping
Full reviews
Frequently asked questions
Is TMates cheaper than Trimi?
Trimi starts lower on semaglutide (Compounded — $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14.). Trimi starts lower on tirzepatide (Compounded — $125/mo on the annual plan (billed yearly). Verified 2026-07-14.). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide — TMates or Trimi?
Trimi starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are TMates and Trimi compounded or brand-name?
TMates offers compounded glp-1 with bundled clinical support. Trimi offers compounded semaglutide and compounded tirzepatide — once-weekly at-home injection. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from TMates to Trimi?
Yes — switching between TMates and Trimi is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare TMates and Trimi to other programs
- TMates vs ShedRx · Trimi vs ShedRx
- TMates vs Direct Meds · Trimi vs Direct Meds
- TMates vs Sprout Health · Trimi vs Sprout Health
- TMates vs Mochi Health · Trimi vs Mochi Health
- TMates vs Henry Meds · Trimi vs Henry Meds
- TMates vs Calibrate · Trimi vs Calibrate
- TMates vs Embody · Trimi vs Embody
- TMates vs Found · Trimi vs Found
Related guides
RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included and Compounded — $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. are starting tiers, not your guaranteed long-term cost.