Quick answer
Synergy Rx and TMates both offer GLP-1 telehealth, but they package medication, support, and pricing differently. The right choice depends on whether you weight cost, clinical touch, or formulation flexibility highest.
Side-by-side comparison
| Feature | Synergy Rx | TMates |
|---|---|---|
| Best for | All-50-state compounded GLP-1 shoppers comparing broad menus with named pharmacies | Compounded GLP-1 with hands-on clinical touch |
| Medication type | Compounded semaglutide and tirzepatide — injectable and oral; once-weekly at-home injection | Compounded GLP-1 with bundled clinical support |
| Pricing model | Cash-pay subscription; advertised 'starting at' entry pricing with a live '2026 Promo Applied' banner and a $100 welcome credit | Monthly subscription, dose-tier pricing |
| Semaglutide price | Compounded — injectable 'starting at $199/mo', oral 'starting at $299/mo' (advertised starting price, verified 2026-07-14; '2026 Promo Applied' banner active). | From $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included |
| Tirzepatide price | Compounded — injectable 'starting at $349/mo', oral 'starting at $399/mo' (advertised starting price, verified 2026-07-14). | From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month) |
| Key watchout | The $199 semaglutide figure is an advertised 'starting at' entry price shown with a live '2026 Promo Applied' banner and a $100 welcome credit — confirm the exact ongoing rate and whether the promo is active at enrollment. Injectable tirzepatide starts at $349; oral formats cost more. | The $158 headline is the compounded SEMAGLUTIDE plan (12-month term; $249/mo month-to-month). Tirzepatide costs more ($167/mo on a 12-month plan, $297 month-to-month) — confirm your product and term at checkout |
When to choose Synergy Rx
- You want compounded semaglutide or tirzepatide (injectable or oral) on a cash-pay plan in all 50 states
- You value named dispensing pharmacies (Belmar, Strive, Epiq Scripts, Casa Pharma Rx)
- You value an upfront compounding disclosure in the FAQ
- You’re comfortable confirming the exact ongoing rate (the $199 is an advertised 'starting at' with a promo banner)
Check current Synergy Rx pricing →
When to choose TMates
- You want a compounded program with clinical check-ins built in
- You'd rather pay one bundled monthly fee than line items
- You want responsive messaging with prescribers
- You're comfortable with a longer onboarding intake in exchange for support
Check current TMates pricing →
Full reviews
Frequently asked questions
Is Synergy Rx cheaper than TMates?
TMates starts lower on semaglutide (From $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included). TMates starts lower on tirzepatide (From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month)). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide — Synergy Rx or TMates?
TMates starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are Synergy Rx and TMates compounded or brand-name?
Synergy Rx offers compounded semaglutide and tirzepatide — injectable and oral; once-weekly at-home injection. TMates offers compounded glp-1 with bundled clinical support. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Synergy Rx to TMates?
Yes — switching between Synergy Rx and TMates is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Synergy Rx and TMates to other programs
- Synergy Rx vs ShedRx · TMates vs ShedRx
- Synergy Rx vs Direct Meds · TMates vs Direct Meds
- Synergy Rx vs Sprout Health · TMates vs Sprout Health
- Synergy Rx vs Mochi Health · TMates vs Mochi Health
- Synergy Rx vs Henry Meds · TMates vs Henry Meds
- Synergy Rx vs Calibrate · TMates vs Calibrate
- Synergy Rx vs Embody · TMates vs Embody
- Synergy Rx vs Found · TMates vs Found
Related guides
RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Compounded — injectable 'starting at $199/mo', oral 'starting at $299/mo' (advertised starting price, verified 2026-07-14; '2026 Promo Applied' banner active). and $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included are starting tiers, not your guaranteed long-term cost.