Quick answer
Sesame Care typically wins on sticker price for compounded GLP-1, while Enhance MD bundles more clinical support and often a wider menu of options. Choose Sesame Care if you're price-first; choose Enhance MD if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Enhance MD | Sesame Care |
|---|---|---|
| Best for | Shoppers who want GLP-1 inside a fuller metabolic/NAD+ coaching program rather than medication-only | Brand-name GLP-1 with insurance support, subscription program |
| Medication type | Compounded GLP-1 (semaglutide, tirzepatide, combo, microdosing) offered inside a 'Metabolic Reset' program with NAD+ and coaching | Brand-name GLP-1 (Wegovy, Zepbound, Ozempic, Foundayo) via subscription program |
| Pricing model | Premium metabolic-program subscription, the monthly price bundles medication, ongoing provider care, and lab testing (not GLP-1 alone) | Monthly program subscription; medication billed separately |
| Semaglutide price | Compounded, 'GLP-1 Core' $212/mo bundled program ($112 first month), verified 2026-07-14. Price reflects the metabolic program, not GLP-1 alone. | Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month') |
| Tirzepatide price | Compounded, 'GLP-1 Advanced' $280/mo; combo 'GLP-1 Elite' $322/mo; microdosing tirzepatide $169/mo, all bundled-program prices, verified 2026-07-14. | Zepbound® from $299/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), medication billed separately, verified 2026-07-25 |
| Key watchout | The $212–$322/mo figures are the BUNDLED program price, verified first-party to include '4 Weeks of Medication', 'Ongoing Provider Care & Support', and 'Metabolic Lab Testing Every 6 Months', NOT the cost of the GLP-1 medication alone. A first-month discount applies (e.g. $112 first month on GLP-1 Core). | Program fee excludes medication, total cost depends on medication path and coverage |
When to choose Enhance MD
- You want GLP-1 inside a structured metabolic program (provider care + periodic lab testing), not medication-only
- You’re comparing NAD+/longevity-style programs, not just low-cost GLP-1
- You value an upfront 'compounded / not FDA-approved' disclosure
- You’re comfortable that the monthly price bundles services beyond the medication
Check current Enhance MD pricing →
When to choose Sesame Care
- You want brand-name medication (Wegovy, Zepbound, Ozempic, Foundayo) rather than compounded
- You already have insurance and want a clinician who can prescribe brand-name GLP-1
- You'd use the annual plan to bring the program fee down to $59/month
- You're comfortable with a program fee that's separate from medication cost
Check current Sesame Care pricing →
Full reviews
Frequently asked questions
Is Enhance MD cheaper than Sesame Care?
Sesame Care starts lower on semaglutide (Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month')). Enhance MD starts lower on tirzepatide (Compounded, 'GLP-1 Advanced' $280/mo; combo 'GLP-1 Elite' $322/mo; microdosing tirzepatide $169/mo, all bundled-program prices, verified 2026-07-14.). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide, Enhance MD or Sesame Care?
Sesame Care tends to win on semaglutide entry pricing; Enhance MD tends to win on tirzepatide entry pricing. Pick by which medication you'll be on long-term, not by the cheapest entry tier.
Are Enhance MD and Sesame Care compounded or brand-name?
Enhance MD offers compounded glp-1 (semaglutide, tirzepatide, combo, microdosing) offered inside a 'metabolic reset' program with nad+ and coaching. Sesame Care offers brand-name glp-1 (wegovy, zepbound, ozempic, foundayo) via subscription program. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Enhance MD to Sesame Care?
Yes, switching between Enhance MD and Sesame Care is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Enhance MD and Sesame Care to other programs
- Enhance MD vs ShedRx · Sesame Care vs ShedRx
- Enhance MD vs TMates · Sesame Care vs TMates
- Enhance MD vs Direct Meds · Sesame Care vs Direct Meds
- Enhance MD vs Sprout Health · Sesame Care vs Sprout Health
- Enhance MD vs Mochi Health · Sesame Care vs Mochi Health
- Enhance MD vs Henry Meds · Sesame Care vs Henry Meds
- Enhance MD vs Calibrate · Sesame Care vs Calibrate
- Enhance MD vs Embody · Sesame Care vs Embody
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RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Compounded, 'GLP-1 Core' $212/mo bundled program ($112 first month), verified 2026-07-14. Price reflects the metabolic program, not GLP-1 alone. and Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month') are starting tiers, not your guaranteed long-term cost.