Quick answer
Sesame Care typically wins on sticker price for compounded GLP-1, while TMates bundles more clinical support and often a wider menu of options. Choose Sesame Care if you're price-first; choose TMates if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Sesame Care | TMates |
|---|---|---|
| Best for | Brand-name GLP-1 with insurance support, subscription program | Compounded GLP-1 with hands-on clinical touch |
| Medication type | Brand-name GLP-1 (Wegovy, Zepbound, Ozempic, Foundayo) via subscription program | Compounded GLP-1 with bundled clinical support |
| Pricing model | Monthly program subscription; medication billed separately | Monthly subscription, dose-tier pricing |
| Semaglutide price | Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month') | From $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included |
| Tirzepatide price | Zepbound® from $299/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), medication billed separately, verified 2026-07-25 | From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month) |
| Key watchout | Program fee excludes medication, total cost depends on medication path and coverage | The $158 headline is the compounded SEMAGLUTIDE plan (12-month term; $249/mo month-to-month). Tirzepatide costs more ($167/mo on a 12-month plan, $297 month-to-month), confirm your product and term at checkout |
When to choose Sesame Care
- You want brand-name medication (Wegovy, Zepbound, Ozempic, Foundayo) rather than compounded
- You already have insurance and want a clinician who can prescribe brand-name GLP-1
- You'd use the annual plan to bring the program fee down to $59/month
- You're comfortable with a program fee that's separate from medication cost
Check current Sesame Care pricing →
When to choose TMates
- You want a compounded program with clinical check-ins built in
- You'd rather pay one bundled monthly fee than line items
- You want responsive messaging with prescribers
- You're comfortable with a longer onboarding intake in exchange for support
Check current TMates pricing →
Full reviews
Frequently asked questions
Is Sesame Care cheaper than TMates?
Sesame Care starts lower on semaglutide (Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month')). TMates starts lower on tirzepatide (From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month)). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide, Sesame Care or TMates?
Sesame Care tends to win on semaglutide entry pricing; TMates tends to win on tirzepatide entry pricing. Pick by which medication you'll be on long-term, not by the cheapest entry tier.
Are Sesame Care and TMates compounded or brand-name?
Sesame Care offers brand-name glp-1 (wegovy, zepbound, ozempic, foundayo) via subscription program. TMates offers compounded glp-1 with bundled clinical support. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Sesame Care to TMates?
Yes, switching between Sesame Care and TMates is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Sesame Care and TMates to other programs
- Sesame Care vs ShedRx · TMates vs ShedRx
- Sesame Care vs Direct Meds · TMates vs Direct Meds
- Sesame Care vs Sprout Health · TMates vs Sprout Health
- Sesame Care vs Mochi Health · TMates vs Mochi Health
- Sesame Care vs Henry Meds · TMates vs Henry Meds
- Sesame Care vs Calibrate · TMates vs Calibrate
- Sesame Care vs Embody · TMates vs Embody
- Sesame Care vs Found · TMates vs Found
Related guides
RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month') and $158/mo (compounded semaglutide, 12-month plan; $249/mo month-to-month); medication and visits included are starting tiers, not your guaranteed long-term cost.