Quick answer
Sesame Care typically wins on sticker price for compounded GLP-1, while TMates bundles more clinical support and often a wider menu of options. Choose Sesame Care if you're price-first; choose TMates if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Sesame Care | TMates |
|---|---|---|
| Best for | Low upfront consult fee — pay-per-visit shoppers | Compounded GLP-1 with hands-on clinical touch |
| Medication type | Brand-name GLP-1 prescribing via marketplace clinicians | Compounded GLP-1 with bundled clinical support |
| Pricing model | Per-visit or membership; medication separate | Monthly subscription, dose-tier pricing |
| Semaglutide price | Visit cost + medication via insurance or pharmacy | From $179/mo |
| Tirzepatide price | Visit cost + medication via insurance or pharmacy | From $249/mo |
| Key watchout | Marketplace model — provider quality varies; confirm credentials before booking | Confirm what the higher tiers include vs the entry tier |
When to choose Sesame Care
- You want a single low-cost consult, not a recurring membership
- You already have insurance and want a clinician who can prescribe brand-name GLP-1
- You're comfortable evaluating individual clinician profiles
- You want the freedom to use any pharmacy after the consult
Check current Sesame Care pricing →
When to choose TMates
- You want a compounded program with clinical check-ins built in
- You'd rather pay one bundled monthly fee than line items
- You want responsive messaging with prescribers
- You're comfortable with a longer onboarding intake in exchange for support
Check current TMates pricing →
Full reviews
Frequently asked questions
Is Sesame Care cheaper than TMates?
Neither Sesame Care nor TMates is uniformly cheaper — both publish dose-banded and formulation-banded pricing that depends on the exact product, dose, and any insurance pathway. Compare the specific tier you'd be on at each before deciding.
Which is better for semaglutide or tirzepatide — Sesame Care or TMates?
Both Sesame Care and TMates prescribe semaglutide and tirzepatide where appropriate. Choose based on how each program handles your target medication, not just the entry price.
Are Sesame Care and TMates compounded or brand-name?
Sesame Care offers brand-name glp-1 prescribing via marketplace clinicians. TMates offers compounded glp-1 with bundled clinical support. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Sesame Care to TMates?
Yes — switching between Sesame Care and TMates is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Sesame Care and TMates to other programs
- Sesame Care vs ShedRx · TMates vs ShedRx
- Sesame Care vs Direct Meds · TMates vs Direct Meds
- Sesame Care vs Sprout Health · TMates vs Sprout Health
- Sesame Care vs Mochi Health · TMates vs Mochi Health
- Sesame Care vs Henry Meds · TMates vs Henry Meds
- Sesame Care vs Calibrate · TMates vs Calibrate
- Sesame Care vs Embody · TMates vs Embody
- Sesame Care vs Found · TMates vs Found
RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Visit cost + medication via insurance or pharmacy and $179/mo are starting tiers, not your guaranteed long-term cost.