Quick answer
Direct Meds and Sesame Care both offer GLP-1 telehealth, but they package medication, support, and pricing differently. The right choice depends on whether you weight cost, clinical touch, or formulation flexibility highest.
Side-by-side comparison
| Feature | Direct Meds | Sesame Care |
|---|---|---|
| Best for | Lowest sticker price for compounded GLP-1 | Low upfront consult fee — pay-per-visit shoppers |
| Medication type | Compounded semaglutide and tirzepatide | Brand-name GLP-1 prescribing via marketplace clinicians |
| Pricing model | Flat low monthly price, minimal extras | Per-visit or membership; medication separate |
| Semaglutide price | From $149/mo | Visit cost + medication via insurance or pharmacy |
| Tirzepatide price | From $219/mo | Visit cost + medication via insurance or pharmacy |
| Key watchout | Lean clinical support — works best if you don't need hand-holding | Marketplace model — provider quality varies; confirm credentials before booking |
When to choose Direct Meds
- You're price-sensitive and want the lowest defensible monthly cost
- You're already familiar with GLP-1 dosing and side-effect management
- You don't need a coach or a heavy-touch clinical team
- You want a no-frills, predictable monthly bill
Check current Direct Meds pricing →
When to choose Sesame Care
- You want a single low-cost consult, not a recurring membership
- You already have insurance and want a clinician who can prescribe brand-name GLP-1
- You're comfortable evaluating individual clinician profiles
- You want the freedom to use any pharmacy after the consult
Check current Sesame Care pricing →
Full reviews
Frequently asked questions
Is Direct Meds cheaper than Sesame Care?
Neither Direct Meds nor Sesame Care is uniformly cheaper — both publish dose-banded and formulation-banded pricing that depends on the exact product, dose, and any insurance pathway. Compare the specific tier you'd be on at each before deciding.
Which is better for semaglutide or tirzepatide — Direct Meds or Sesame Care?
Both Direct Meds and Sesame Care prescribe semaglutide and tirzepatide where appropriate. Choose based on how each program handles your target medication, not just the entry price.
Are Direct Meds and Sesame Care compounded or brand-name?
Direct Meds offers compounded semaglutide and tirzepatide. Sesame Care offers brand-name glp-1 prescribing via marketplace clinicians. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Direct Meds to Sesame Care?
Yes — switching between Direct Meds and Sesame Care is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Direct Meds and Sesame Care to other programs
- Direct Meds vs ShedRx · Sesame Care vs ShedRx
- Direct Meds vs TMates · Sesame Care vs TMates
- Direct Meds vs Sprout Health · Sesame Care vs Sprout Health
- Direct Meds vs Mochi Health · Sesame Care vs Mochi Health
- Direct Meds vs Henry Meds · Sesame Care vs Henry Meds
- Direct Meds vs Calibrate · Sesame Care vs Calibrate
- Direct Meds vs Embody · Sesame Care vs Embody
- Direct Meds vs Found · Sesame Care vs Found
RangeYourself is reader-supported. We may earn a commission when you click on certain links — at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like $149/mo and Visit cost + medication via insurance or pharmacy are starting tiers, not your guaranteed long-term cost.