Quick answer
Trimi typically wins on sticker price for compounded GLP-1, while Synergy Rx bundles more clinical support and often a wider menu of options. Choose Trimi if you're price-first; choose Synergy Rx if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Synergy Rx | Trimi |
|---|---|---|
| Best for | All-50-state compounded GLP-1 shoppers comparing broad menus with named pharmacies | Lowest-cost compounded GLP-1 on an annual plan with a plain 503A disclosure |
| Medication type | Compounded semaglutide and tirzepatide, injectable and oral; once-weekly at-home injection | Compounded semaglutide and compounded tirzepatide, once-weekly at-home injection |
| Pricing model | Cash-pay subscription; advertised 'starting at' entry pricing with a live '2026 Promo Applied' banner and a $100 welcome credit | Flat-membership subscription billed yearly (annual commitment tier); one price covers medication, clinician visits, check-ins, shipping; no separate membership fee; no insurance |
| Semaglutide price | Compounded, injectable 'starting at $199/mo', oral 'starting at $299/mo' (advertised starting price, verified 2026-07-14; '2026 Promo Applied' banner active). | Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. |
| Tirzepatide price | Compounded, injectable 'starting at $349/mo', oral 'starting at $399/mo' (advertised starting price, verified 2026-07-14). | Compounded, $125/mo on the annual plan (billed yearly). Verified 2026-07-14. |
| Key watchout | The $199 semaglutide figure is an advertised 'starting at' entry price shown with a live '2026 Promo Applied' banner and a $100 welcome credit, confirm the exact ongoing rate and whether the promo is active at enrollment. Injectable tirzepatide starts at $349; oral formats cost more. | The $99/mo semaglutide and $125/mo tirzepatide rates are the ANNUAL plan, BILLED YEARLY (semaglutide = $1,188 charged up front). A month-to-month rate is not published, confirm billing terms before enrolling. |
When to choose Synergy Rx
- You want compounded semaglutide or tirzepatide (injectable or oral) on a cash-pay plan in all 50 states
- You value named dispensing pharmacies (Belmar, Strive, Epiq Scripts, Casa Pharma Rx)
- You value an upfront compounding disclosure in the FAQ
- You’re comfortable confirming the exact ongoing rate (the $199 is an advertised 'starting at' with a promo banner)
Check current Synergy Rx pricing →
When to choose Trimi
- You want the lowest-cost compounded semaglutide ($99/mo) or tirzepatide ($125/mo) with everything bundled
- You’re comfortable with an annual plan billed yearly ($1,188 up front for semaglutide)
- You value an upfront '503A compounding pharmacy' and 'not FDA-approved' disclosure
- You want care via a 50-state clinical network (Arora Health) with free shipping
Full reviews
Frequently asked questions
Is Synergy Rx cheaper than Trimi?
Trimi starts lower on semaglutide (Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14.). Trimi starts lower on tirzepatide (Compounded, $125/mo on the annual plan (billed yearly). Verified 2026-07-14.). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide, Synergy Rx or Trimi?
Trimi starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are Synergy Rx and Trimi compounded or brand-name?
Synergy Rx offers compounded semaglutide and tirzepatide, injectable and oral; once-weekly at-home injection. Trimi offers compounded semaglutide and compounded tirzepatide, once-weekly at-home injection. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Synergy Rx to Trimi?
Yes, switching between Synergy Rx and Trimi is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Synergy Rx and Trimi to other programs
- Synergy Rx vs ShedRx · Trimi vs ShedRx
- Synergy Rx vs TMates · Trimi vs TMates
- Synergy Rx vs Direct Meds · Trimi vs Direct Meds
- Synergy Rx vs Sprout Health · Trimi vs Sprout Health
- Synergy Rx vs Mochi Health · Trimi vs Mochi Health
- Synergy Rx vs Henry Meds · Trimi vs Henry Meds
- Synergy Rx vs Calibrate · Trimi vs Calibrate
- Synergy Rx vs Embody · Trimi vs Embody
Related guides
RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Compounded, injectable 'starting at $199/mo', oral 'starting at $299/mo' (advertised starting price, verified 2026-07-14; '2026 Promo Applied' banner active). and Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. are starting tiers, not your guaranteed long-term cost.