Quick answer
Yucca Health typically wins on sticker price for compounded GLP-1, while Synergy Rx bundles more clinical support and often a wider menu of options. Choose Yucca Health if you're price-first; choose Synergy Rx if you want hands-on prescribing or brand-name access.
Side-by-side comparison
| Feature | Synergy Rx | Yucca Health |
|---|---|---|
| Best for | All-50-state compounded GLP-1 shoppers comparing broad menus with named pharmacies | Low advertised entry price on compounded GLP-1 with plain FDA disclosures and all-50-state provider coverage |
| Medication type | Compounded semaglutide and tirzepatide, injectable and oral; once-weekly at-home injection | Compounded semaglutide and tirzepatide, once-weekly injection ('Semaglutide+' / 'Tirzepatide+'); also sells NAD+ and Sermorelin (out of registry scope) |
| Pricing model | Cash-pay subscription; advertised 'starting at' entry pricing with a live '2026 Promo Applied' banner and a $100 welcome credit | 6-month prescription plans billed monthly/quarterly/6-month; advertised new-patient entry pricing; full pricing shared after intake |
| Semaglutide price | Compounded, injectable 'starting at $199/mo', oral 'starting at $299/mo' (advertised starting price, verified 2026-07-14; '2026 Promo Applied' banner active). | Compounded, '$146 /mo 6 month supply' ('*New Patients, Semaglutide 6-month plan'; 'as low as' entry rate, promo code YUCCA4LIFE '$146 /mo For life' active; full pricing intake-gated) |
| Tirzepatide price | Compounded, injectable 'starting at $349/mo', oral 'starting at $399/mo' (advertised starting price, verified 2026-07-14). | Compounded, '$258 /mo 6 month supply' (new-patient 6-month plan entry rate; full pricing intake-gated) |
| Key watchout | The $199 semaglutide figure is an advertised 'starting at' entry price shown with a live '2026 Promo Applied' banner and a $100 welcome credit, confirm the exact ongoing rate and whether the promo is active at enrollment. Injectable tirzepatide starts at $349; oral formats cost more. | The $146/mo figure is a NEW-PATIENT 'as low as' rate on a 6-month semaglutide plan, shown site-wide with an 'Exclusive Lifetime Offer' promo code (YUCCA4LIFE), Yucca's own FAQ says full pricing 'is shared after intake once eligibility is confirmed.' Confirm your dose's ongoing rate at intake. Pharmacies are not named. |
When to choose Synergy Rx
- You want compounded semaglutide or tirzepatide (injectable or oral) on a cash-pay plan in all 50 states
- You value named dispensing pharmacies (Belmar, Strive, Epiq Scripts, Casa Pharma Rx)
- You value an upfront compounding disclosure in the FAQ
- You’re comfortable confirming the exact ongoing rate (the $199 is an advertised 'starting at' with a promo banner)
Check current Synergy Rx pricing →
When to choose Yucca Health
- You want a low advertised entry price on compounded semaglutide or tirzepatide
- You value an upfront 'not FDA-approved' compounding disclosure in the FAQ
- You want provider coverage in all 50 states with free 2-day shipping
- You're comfortable confirming your exact ongoing rate at intake (pricing beyond the entry offer is shared after eligibility)
Check current Yucca Health pricing →
Full reviews
Frequently asked questions
Is Synergy Rx cheaper than Yucca Health?
Yucca Health starts lower on semaglutide (Compounded, '$146 /mo 6 month supply' ('*New Patients, Semaglutide 6-month plan'; 'as low as' entry rate, promo code YUCCA4LIFE '$146 /mo For life' active; full pricing intake-gated)). Yucca Health starts lower on tirzepatide (Compounded, '$258 /mo 6 month supply' (new-patient 6-month plan entry rate; full pricing intake-gated)). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide, Synergy Rx or Yucca Health?
Yucca Health starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are Synergy Rx and Yucca Health compounded or brand-name?
Synergy Rx offers compounded semaglutide and tirzepatide, injectable and oral; once-weekly at-home injection. Yucca Health offers compounded semaglutide and tirzepatide, once-weekly injection ('semaglutide+' / 'tirzepatide+'); also sells nad+ and sermorelin (out of registry scope). If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Synergy Rx to Yucca Health?
Yes, switching between Synergy Rx and Yucca Health is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Synergy Rx and Yucca Health to other programs
- Synergy Rx vs ShedRx · Yucca Health vs ShedRx
- Synergy Rx vs TMates · Yucca Health vs TMates
- Synergy Rx vs Direct Meds · Yucca Health vs Direct Meds
- Synergy Rx vs Sprout Health · Yucca Health vs Sprout Health
- Synergy Rx vs Mochi Health · Yucca Health vs Mochi Health
- Synergy Rx vs Henry Meds · Yucca Health vs Henry Meds
- Synergy Rx vs Calibrate · Yucca Health vs Calibrate
- Synergy Rx vs Embody · Yucca Health vs Embody
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RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Compounded, injectable 'starting at $199/mo', oral 'starting at $299/mo' (advertised starting price, verified 2026-07-14; '2026 Promo Applied' banner active). and Compounded, '$146 /mo 6 month supply' ('*New Patients, Semaglutide 6-month plan'; 'as low as' entry rate, promo code YUCCA4LIFE '$146 /mo For life' active; full pricing intake-gated) are starting tiers, not your guaranteed long-term cost.