Men typically tolerate higher GLP-1 doses than women on average and have different weight-loss trajectories. The right program for men weighs dose flexibility, muscle preservation guidance, and total monthly cost.
Who this list is for
Men comparing GLP-1 programs with attention to muscle preservation and dose tolerance.
Ranked programs: 5 verified, $99–$249/mo all-in (prices monitored daily, last change detected November 3, 2026)
| Provider | All-in monthly | Semaglutide | Tirzepatide | Compounded vs brand | Insurance accepted? | Last verified | Price source | |
|---|---|---|---|---|---|---|---|---|
| $99/mo12-month plan rate | From $99/mo on the 12-month plan (billed $1,188 every 12 months); $149 per 4 weeks on the monthly plan; same price at any dose (compounded semaglutide, homepage-verified 2026-11-03) | From $149/mo on the 12-month plan (billed $1,788 every 12 months); $199 per 4 weeks on the monthly plan; same price at any dose (compounded tirzepatide, homepage-verified 2026-11-03) | Both | No | joinsprouthealth.com ↗ | See pricing → | ||
| $158/mo12-month plan rate | Compounded, $158/mo on the 12-month plan ($1,900 billed per term); $175/mo on the 6-month plan; $217/mo on the 3-month plan; $249/mo month-to-month. Verified 2026-07-14. | From $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month) | Compounded | No | tmates.com ↗ | See pricing → | ||
$159/mo12-month plan rate(oral sublingual; the $199 entry price is the GLP-1 lozenge; on the injectable semaglutide, Shed's own surfaces disagree ($199/mo on its product-page plan table vs $249/mo on its category card, both live 2026-09-03))intro: 30% off your first month via the RangeYourself affiliate link (landing page carries medPromo=Shed10); recurring price applies from month 2, verified 2026-07-21 See pricing → | $159/mo12-month plan rate(oral sublingual; the $199 entry price is the GLP-1 lozenge; on the injectable semaglutide, Shed's own surfaces disagree ($199/mo on its product-page plan table vs $249/mo on its category card, both live 2026-09-03))intro: 30% off your first month via the RangeYourself affiliate link (landing page carries medPromo=Shed10); recurring price applies from month 2, verified 2026-07-21 | Compounded, $159/mo on the 12-month plan; $179/mo on the 6-month plan; $199/mo month-to-month. Verified 2026-09-03. | From $349/mo (compounded injection), verified 2026-09-03 on tryshed.com/products/category/weight-loss (unchanged since 2026-07-21) | Both | No | tryshed.com ↗ | See pricing → | |
| $179/mo | From $179/mo | From $179/mo | Compounded | No | henrymeds.com ↗ | See pricing → | ||
$249/mo(oral sublingual; injectable semaglutide is $297/mo; the $249 all-inclusive rate is sublingual) See pricing → | $249/mo(oral sublingual; injectable semaglutide is $297/mo; the $249 all-inclusive rate is sublingual) | From $249/mo (sublingual) to $297/mo (injection), all-inclusive, verified 2026-07-25 on Direct Meds' own product pages ('$249.00 / month … Billed Every Month', '0% OFF') | From $299/mo (sublingual) to $399/mo (injection), all-inclusive, verified 2026-07-25 | Compounded | No | directmeds.com ↗ | See pricing → |
Prices verified against provider pages on ; see how we verify.
Why we ranked them this way
- Men typically respond at higher GLP-1 doses than women due to higher average body weight. Programs with smooth dose-escalation pricing matter more here.
- GLP-1 medications can accelerate lean mass loss alongside fat loss. Programs that prompt strength training and protein intake yield better body-composition outcomes.
- Most cash-pay men do best with mid-priced compounded programs, sub-$200/month entry tiers, with smooth escalation pricing.
The picks in detail
Sprout Health
Best for: Balance of price and clinical support.
Watchout: The $99 (semaglutide) and $149 (tirzepatide) figures are Sprout's 12-month plan rates, billed $1,188 and $1,788 every 12 months. The monthly plan is $149 (semaglutide) and $199 (tirzepatide) per 4 weeks, billed every 4 weeks, not per calendar month. Sprout states 'Same price at any dose.' Refund eligibility narrows once a provider has reviewed the intake (refund policy, read 2026-10-06)..
Pricing: $99/mo all-in (medication included), semaglutide from $99/mo on the 12-month plan (billed $1,188 every 12 months); $149 per 4 weeks on the monthly plan; same price at any dose (compounded semaglutide, homepage-verified 2026-11-03), tirzepatide from $149/mo on the 12-month plan (billed $1,788 every 12 months); $199 per 4 weeks on the monthly plan; same price at any dose (compounded tirzepatide, homepage-verified 2026-11-03).
TMates
Best for: Compounded GLP-1 with hands-on clinical touch.
Watchout: The $158 headline is the compounded SEMAGLUTIDE plan (12-month term; $249/mo month-to-month). Tirzepatide costs more ($167/mo on a 12-month plan, $297 month-to-month), confirm your product and term at checkout.
Pricing: $158/mo all-in (medication included), semaglutide compounded, $158/mo on the 12-month plan ($1,900 billed per term); $175/mo on the 6-month plan; $217/mo on the 3-month plan; $249/mo month-to-month. verified 2026-07-14., tirzepatide from $167/mo (compounded tirzepatide, 12-month plan; $297/mo month-to-month).
ShedRx
Best for: Broad GLP-1 menu and multiple formats.
Watchout: Verify higher-dose pricing and exact formulation before checkout.
Pricing: $159/mo all-in (medication included), semaglutide compounded, $159/mo on the 12-month plan; $179/mo on the 6-month plan; $199/mo month-to-month. verified 2026-09-03., tirzepatide from $349/mo (compounded injection), verified 2026-09-03 on tryshed.com/products/category/weight-loss (unchanged since 2026-07-21).
Henry Meds
Best for: Simple compounded program with broad availability.
Watchout: Limited brand-name path if you later want Wegovy/Zepbound.
Pricing: $179/mo all-in (medication included), semaglutide from $179/mo, tirzepatide from $179/mo.
Direct Meds
Best for: Multiple compounded formats (injection and sublingual).
Watchout: Pricing varies by format and page, product-page 'all-inclusive' rates differ from homepage promo cards; confirm your format's rate at checkout.
Pricing: $249/mo all-in (medication included), semaglutide from $249/mo (sublingual) to $297/mo (injection), all-inclusive, verified 2026-07-25 on direct meds' own product pages ('$249.00 / month … billed every month', '0% off'), tirzepatide from $299/mo (sublingual) to $399/mo (injection), all-inclusive, verified 2026-07-25.
Frequently asked questions
Do GLP-1s work differently in men?
The active ingredients work the same way. Men typically tolerate higher doses on average and respond well to standard dose-escalation protocols. Average percent weight loss is similar across sexes in clinical trials.
Will GLP-1 cause muscle loss in men?
GLP-1-induced weight loss includes both fat and lean mass. Men who pair GLP-1 with strength training (2–4 sessions/week) and adequate protein (~1g per pound of target body weight) preserve far more lean mass.
Is testosterone affected by GLP-1?
Significant weight loss can raise endogenous testosterone in men with previously elevated body fat. Some men report energy and libido improvements as weight comes down.
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