Quick answer
Sesame Care and Trimi both offer GLP-1 telehealth, but they package medication, support, and pricing differently. The right choice depends on whether you weight cost, clinical touch, or formulation flexibility highest.
Side-by-side comparison
| Feature | Sesame Care | Trimi |
|---|---|---|
| Best for | Brand-name GLP-1 with insurance support, subscription program | Lowest-cost compounded GLP-1 on an annual plan with a plain 503A disclosure |
| Medication type | Brand-name GLP-1 (Wegovy, Zepbound, Ozempic, Foundayo) via subscription program | Compounded semaglutide and compounded tirzepatide, once-weekly at-home injection |
| Pricing model | Monthly program subscription; medication billed separately | Flat-membership subscription billed yearly (annual commitment tier); one price covers medication, clinician visits, check-ins, shipping; no separate membership fee; no insurance |
| Semaglutide price | Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month') | Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. |
| Tirzepatide price | Zepbound® from $299/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), medication billed separately, verified 2026-07-25 | Compounded, $125/mo on the annual plan (billed yearly). Verified 2026-07-14. |
| Key watchout | Program fee excludes medication, total cost depends on medication path and coverage | The $99/mo semaglutide and $125/mo tirzepatide rates are the ANNUAL plan, BILLED YEARLY (semaglutide = $1,188 charged up front). A month-to-month rate is not published, confirm billing terms before enrolling. |
When to choose Sesame Care
- You want brand-name medication (Wegovy, Zepbound, Ozempic, Foundayo) rather than compounded
- You already have insurance and want a clinician who can prescribe brand-name GLP-1
- You'd use the annual plan to bring the program fee down to $59/month
- You're comfortable with a program fee that's separate from medication cost
Check current Sesame Care pricing →
When to choose Trimi
- You want the lowest-cost compounded semaglutide ($99/mo) or tirzepatide ($125/mo) with everything bundled
- You’re comfortable with an annual plan billed yearly ($1,188 up front for semaglutide)
- You value an upfront '503A compounding pharmacy' and 'not FDA-approved' disclosure
- You want care via a 50-state clinical network (Arora Health) with free shipping
Full reviews
Frequently asked questions
Is Sesame Care cheaper than Trimi?
Trimi starts lower on semaglutide (Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14.). Trimi starts lower on tirzepatide (Compounded, $125/mo on the annual plan (billed yearly). Verified 2026-07-14.). Higher doses can shift the picture, so confirm pricing at the dose you're likely to use long-term.
Which is better for semaglutide or tirzepatide, Sesame Care or Trimi?
Trimi starts lower on both semaglutide and tirzepatide based on listed entry pricing. That said, the right pick is the program whose support model and formulation match what you actually need.
Are Sesame Care and Trimi compounded or brand-name?
Sesame Care offers brand-name glp-1 (wegovy, zepbound, ozempic, foundayo) via subscription program. Trimi offers compounded semaglutide and compounded tirzepatide, once-weekly at-home injection. If you specifically want brand-name Wegovy or Zepbound, lean toward whichever explicitly supports brand access; if compounded is fine, both can typically meet that need.
Can I switch from Sesame Care to Trimi?
Yes, switching between Sesame Care and Trimi is straightforward in most states. You typically finish your current month, complete a new intake with the other provider, and they handle the prescription. Watch for overlap on auto-renewal billing and confirm any dose-tier or formulation differences with the new clinician before your next shipment.
Compare Sesame Care and Trimi to other programs
- Sesame Care vs ShedRx · Trimi vs ShedRx
- Sesame Care vs TMates · Trimi vs TMates
- Sesame Care vs Direct Meds · Trimi vs Direct Meds
- Sesame Care vs Sprout Health · Trimi vs Sprout Health
- Sesame Care vs Mochi Health · Trimi vs Mochi Health
- Sesame Care vs Henry Meds · Trimi vs Henry Meds
- Sesame Care vs Calibrate · Trimi vs Calibrate
- Sesame Care vs Embody · Trimi vs Embody
Related guides
RangeYourself is reader-supported. We may earn a commission when you click on certain links, at no extra cost to you. Editorial recommendations are made independently. Pricing reflects publicly listed entry tiers as of May 2026 and may change. Numbers like Wegovy® pill from $149/mo cash + program subscription $59/mo (12-month commitment) to $99/mo (month-to-month, no commitment), full tier ladder verified 2026-07-25 on sesamecare.com/service/online-weight-loss-program (FAQ: 'Month-to-Month Plan: Billed every month at $99 per month') and Compounded, $99/mo on the annual plan, BILLED YEARLY ($1,188/yr up front). Verified 2026-07-14. are starting tiers, not your guaranteed long-term cost.